One of the best things about Italy, besides the history and amazing architecture is the food and wine. Right outside of our hotel was Alex Cafe Gestione Ci.Bi. Sas. It looks like a little glass house and offers amazing pasta, wine, and service.
I realize Vatican City is independent city-state from Rome, but this is a sight you do not want to miss when you are in the area. St. Peter's Basilica opens at 7:00 a.m. and if you arrive at 6:00 a.m. you will beat the lines and the tour buses. This will also give you time to take pictures of the famed St. Peter's Square before it is packed with people.
If you need a break during sightseeing grab a slice of pizza and glass of vino at Piazza Navona. This open space was built in 1st century AD and is home to breathtaking sculptures and architecture with prime people watching as artists paint, dance, and play music.